Patent · US Active

High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs

US9950057B2 · kind B2 · utility

23Cited by

60References

17Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Yoshihiro Kawaoka · Middleton, US
Gabriele Neumann · Madison, US
Jihui Ping · Madison, US

Key dates

Filing date	Jul 15, 2014
Grant date	Apr 24, 2018
Priority date	—
Expiry date	Jul 15, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2760/16134
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.