Carbazole compounds for in vivo imaging
US9951011B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2014 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Sep 19, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0446
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known TSPO-binding radiotracers. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said precursor compound. Other aspects of the invention include a method for the synthesis of the in vivo imaging agent of the invention comprising use of the precursor compound of the invention, a kit for carrying out said method, and a cassette for carrying out an automated version of said method. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.