Methods of making 2-halonicotinonitriles
US9951020B2 · kind B2 · utility
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Key dates
| Filing date | Feb 19, 2016 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Feb 19, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The dehydrating agent substantially retards dimerization of the alkylidene nitrile during the reaction. The enamine intermediate that forms from the reaction is cyclized using a halide donor to make the 2-halonicotinonitrile.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.