Reversible heparin molecules and methods of making and using the same

US9951149B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Rensselaer Polytechnic Institute · US
• NUtech Ventures · US

Inventors

• Jian Liu · Los Angeles, US
• Yongmei Xu · Durham, US
• Robert J. Linhardt · Iowa City, US
• Edward Bruce Harris · Lincoln, US

Key dates

• Filing date: Jun 17, 2014
• Grant date: Apr 24, 2018
• Expiry date: Jun 17, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.