Micrornas that silence tau expression
US9951330B2 · kind B2 · utility
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Key dates
| Filing date | Jul 11, 2014 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Jul 11, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/178
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with abnormal tau expression, e.g., tauopathies, using the 3′untranslated region (UTR) of the tau messenger RNA (mRNA) as a target, specifically using microRNAs that regulate the expression of tau. This invention is also in the field of screening for, identifying, and diagnosing such diseases. Specifically, this invention provides biomarkers for these diseases in the form of microRNAs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.