Activated formylglycine-generating enzymes and methods of producing and using the same
US9951367B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Dec 18, 2015 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Feb 15, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y108/99
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.