Tissue imaging and visualization of lesions using reflectance and autofluorescence measurements
US9952157B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2013 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Feb 13, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/0686
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.