Biomarker method
US9953417B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 2014 |
| Grant date | Apr 24, 2018 |
| Priority date | — |
| Expiry date | Oct 3, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06V20/698
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A spatial distribution of cells or sub-cellular structures of a subject is quantified by receiving image data that includes a plurality of biomarkers and processing the image data to obtain a set of coordinates. Each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers. The set of coordinates is processed into a two-dimensional symmetric matrix. Each element of the matrix indicates the frequency of a cell or sub-cellular structure represented by a first biomarker or combination of biomarkers being observed within an interaction distance of a cell or sub-cellular structure represented by a second biomarker or combination of biomarkers. A classifier assigns the subject to a group or category based on the matrix. A toxicity and/or efficacy of one or more interventions is assessed based on a comparison of the spatial distribution to one or more predetermined reference or control distributions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.