Vaccines against antigens involved in therapy resistance and methods of using same
US9956276B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 21, 2013 |
| Grant date | May 1, 2018 |
| Priority date | — |
| Expiry date | Jan 23, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER3 polypeptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.