Contrast agents, methods for preparing contrast agents, and methods of imaging
US9956304B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 5, 2013 |
| Grant date | May 1, 2018 |
| Priority date | — |
| Expiry date | Jun 17, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd3+, each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion; the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image; and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.