Cyclohexen-1-yl-pyridin-2-yl-1h-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators

US9957254B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Christopher M. Adams · Arlington, US
• David B. Belanger · Cambridge, US
• Doug Bevan · Chelmsford, US
• Philippe Bolduc · Weymouth, US
• Takeru Ehara · Tsukuba, JP
• Luciana Ferrara · Stoughton, US
• Nan Ji · Arlington, US
• Mitsunori Kato · Cambridge, US
• Erik Meredith · Cambridge, US
• Muneto Mogi · Waltham, US
• James J. Powers · Waltham, US
• Ganesh Prasanna · Acton, US

Key dates

• Filing date: Jul 2, 2015
• Grant date: May 1, 2018
• Expiry date: Jul 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.