Arrangement and process for optical analysis and specific isolation of biological samples

US9958435B2 · kind B2 · utility

Assignee

• Siemens Healthcare Diagnostics Inc. · US

Inventors

• Joachim Bangert · Erlangen, DE
• Katja Friedrich · Erlenbach a.Main, DE
• Walter Gumbrecht · Herzogenaurach, DE
• Karsten Hiltawsky · Stockelsdorf, DE
• Peter Paulicka · Erlangen, DE
• Manfred Stanzel · Erlangen, DE

Key dates

• Filing date: Apr 16, 2012
• Grant date: May 1, 2018
• Expiry date: Oct 14, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2015/1006
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A process is disclosed for detecting cells in a liquid sample, which includes: i) filtration of the liquid sample through a porous membrane which is suitable for retaining detectable cells, where at least one subregion of a support is configured as transparent supporting body and the membrane is arranged over its area on the transparent supporting body in such a way that detectable cells are retained on at least part of the surface of the membrane and that at least part of the sample liquid passes through the membrane, ii) application of a liquid optical medium which has essentially the same refractive index as the supporting body, and iii) optical measurement of at least a subarea of the membrane in order to detect detectable cells.