Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose

US9962446B2 · kind B2 · utility

Assignee

• DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

• Nicholas S. Grasman · Midland, US
• Steven J. Guillaudeu · Midland, US
• Mark J. Hall · Gaylord, US
• Uma Shrestha · Bay City, US
• Maureen L. Rose · Midland, US
• William W. Porter, III · Midland, US
• Wesley J. Spaulding · Freeland, US
• Kevin O'Donnell · Midland, US
• True L. Rogers · Midland, US

Key dates

• Filing date: Jul 12, 2013
• Grant date: May 8, 2018
• Expiry date: Oct 26, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.