Cationic lipids for therapeutic agent delivery formulations

US9963424B2 · kind B2 · utility

Assignee

• NITTO DENKO CORPORATION · JP

Inventors

• Yoshiro Niitsu · Sapporo, JP
• Victor Knopov · Oceanside, US
• Joseph E. Payne · San Diego, US
• Zheng Hou · San Diego, US
• John A. Gaudette · Poway, US
• Violetta Akopian · Oceanside, US
• Richard P. Witte · San Diego, US
• Mohammad Ahmadian · Carlsbad, US
• Loren A. Perelman · San Diego, US
• Yasunobu Tanaka · Osaka, JP
• Priya Karmali · San Diego, US
• Sridhar C. Nagarajan · San Diego, US

Key dates

• Filing date: Jan 25, 2016
• Grant date: May 8, 2018
• Expiry date: Jan 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/113
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Here described are compounds of formula I:wherein R1 and R2 are independently selected from C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl; R3 and R4 are independently selected from C1 to C6 alkyl and C2 to C6 alkanol; X is selected from —CH2—, —S—, and —O—, or X is absent; Y is selected from —(CH2)n, —S(CH2)n—, —O(CH2)n—, -thiophene-, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z− is a counterion. Also described herein are compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents, and methods of using these compositions and formulations.