Human-mouse chimeric anti-CD147 antibody with non-fucosylated glycosylation

US9963506B2 · kind B2 · utility

Assignee

• FOURTH MILITARY MEDICAL UNIVERSITY · CN

Inventors

• Zhinan Chen · Dizhai, CN
• Zheng Zhang · Beijing, CN
• Yang Zhang · San Diego, US
• Fei Feng · Xi'an, CN
• Muren Huhe · Xi'an, CN
• Xiangmin Yang · Xi'an, CN

Key dates

• Filing date: Oct 7, 2015
• Grant date: May 8, 2018
• Expiry date: Oct 7, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a nucleotide sequence comprising the sequence of SEQ ID NO: 5, and/or sequence of SEQ ID NO: 6, vector and host cell line comprising the nucleotide. The present disclosure also relates to an antibody that binds to extracellular region of human CD147, wherein the antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO: 2, and/or a light chain variable region having the amino acid sequence of SEQ ID NO: 1, and the antibody contains a glycoform lacking both fucose residues and xylose residues, pharmaceutical composition comprising the antibody or fragment thereof, the method of producing the antibody or fragment thereof, and use of the pharmaceutical composition in treatment of CD147 expression-related diseases.