Chimaeric surrogate light chains (SLC) comprising human VpreB
US9963716B2 · kind B2 · utility
12Cited by
45References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 26, 2014 |
| Grant date | May 8, 2018 |
| Priority date | — |
| Expiry date | Jun 8, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8518
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.