LCMV-GP-VSV-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors

US9963718B2 · kind B2 · utility

Assignee

• ViraTherapeutics GmbH · AT

Inventors

• Dorothee Von Laer · Innsbruck, AT
• Tsanan Heimann · Mainz, DE

Key dates

• Filing date: Apr 7, 2017
• Grant date: May 8, 2018
• Expiry date: Apr 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2810/6072
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.