Stimuli responsive compositions for iron chelation
US9968633B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2015 |
| Grant date | May 15, 2018 |
| Priority date | — |
| Expiry date | Oct 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F220/282
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.