Scaffold with drug coating for treating restenosis and preparation method thereof

US9968717B2 · kind B2 · utility

Assignee

• Xiyuan Hospital of China Academy of Chinese Medical Sciences · CN

Inventors

• Dazhuo Shi · Beijing, CN
• Jiangang Liu · Shrewsbury, US
• Fuhai Zhao · Beijing, CN
• Xin Wang · Shanghai, CN
• Dawu Zhang · Beijing, CN
• Peili Wang · Beijing, CN
• Jianpeng Du · Beijing, CN
• Yuanyuan Cui · Beijing, CN
• Lei Zhang · Beijing, CN
• Kai Cui · Shanxi, CN
• Zhengcai Zhang · Beijing, CN

Key dates

• Filing date: Apr 20, 2015
• Grant date: May 15, 2018
• Expiry date: Apr 20, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2420/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Disclosed is a stent with a drug coating for preventing and treating restenosis, comprising a stent and a drug coating covering the surface of the stent. The active ingredients in the drug coating are guaiane sesquiterpene compounds P1, P2 and P3. P1 is Zedoalactone B, P2 is a stereoisomer of P1, and P3 is Zedoarondiol. Compared with an existing sirolimus eluting stent, the present drug eluting stent can inhibit the intimal hyperplasia and the inflammatory reactions of vascular walls, and promote the endothelialization of blood vessels after the stent is implanted, and thus can prevent the long-term thrombotic complications; and has the advantages of small dosage, low cost, and no toxic side effect.