Compounds useful as CCR9 modulators

US9969687B2 · kind B2 · utility

Assignee

• NORGINE BV · NL

Inventors

• Rajagopal Bakthavatchalam · Branford, US
• Manas Kumar Basu · Ghaziabad, IN
• Ajit Kumar Behera · Nayagarh, IN
• Chandregowda Venkateshappa · Noida, IN
• Christopher Alexander Hewson · Grafton, GB
• Sanjay Venkatachalapathi Kadnur · Bengaluru, IN
• Sarkis Barret Kalindjian · Banstead, GB
• Bheemashankar A. Kulkarni · Noida, IN
• Rohit Saxena · Sidhauli, IN
• Juluri Suresh · Hyderabad, IN
• Vellarkad Viswanathan · Bengaluru, IN
• Mohd Zainuddin
• Akila Parvathy Dharshinis · Tirunelveli, IN
• Rajenda Kristam · Bengaluru, IN

Key dates

• Filing date: Dec 22, 2014
• Grant date: May 15, 2018
• Expiry date: Dec 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).