Coupling method for peptide synthesis at elevated temperatures
US9969769B2 · kind B2 · utility
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36Claims
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Key dates
| Filing date | Jul 12, 2017 |
| Grant date | May 15, 2018 |
| Priority date | — |
| Expiry date | Jul 12, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/57581
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improved method for coupling amino acids into peptides or peptidomimetics is disclosed that includes the steps of combining an amino acid, a carbodiimide, an activator additive, and a base at less than 1 equivalent compared to the amino acid to be activated; and carrying out the activation and coupling at a temperature greater than 30° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.