Trophic hormone fusion protein, preparation method and application thereof

US9969786B2 · kind B2 · utility

Assignee

• SUZHOU ALPHAMAB CO., LTD. · CN

Inventors

• Ting Xu · Berkeley, US
• Kangping Guo · Suzhou, CN
• Lihong YUN · 安丰镇, CN

Key dates

• Filing date: Nov 22, 2013
• Grant date: May 15, 2018
• Expiry date: Nov 22, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof. β-subunit of the gonadotropin or thyroid stimulating hormone is fused to an Fc fragment directly or indirectly through a linker, and α-subunit binds to the β-subunit via an affinity between the α-subunit and the β-subunit. The fusion protein has a prolonged half-life and less fluctuating activity.