Pipecolinic acid 4-hydroxylase and method for producing 4-hydroxy amino acid using same
US9969988B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Jan 27, 2015 |
| Grant date | May 15, 2018 |
| Priority date | — |
| Expiry date | Jan 27, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y114/11006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with α-amino acid to produce 4-hydroxy amino acid:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.