Patent · US Active

Method for synthesizing optically active carbonyl compounds

US9975837B2 · kind B2 · utility

4Cited by

4References

18Claims

0Family size

Assignee

BASF SE

Inventors

Mathias Schelwies · Ludwigshafen am Rhein, DE
Rocco Paciello · Bad Dürkheim, DE
Gunnar Heydrich · Schifferstadt, DE
Günter Wegner · Charlotte, US
Gerd-Dieter Tebben · Mannheim, DE
Martin Haubner · Ludwigshafen am Rhein, DE
Andreas Keller · Speyer, DE
Oliver Bey · Niederkirchen, DE
Stephanie RENZ · Ludwigshafen am Rhein, DE
Georg Seeber · Lambsheim, DE

Key dates

Filing date	Dec 18, 2015
Grant date	May 22, 2018
Priority date	—
Expiry date	Dec 18, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I):in which

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.