Inhibitors of HIV-1 entry and methods of use thereof

US9975848B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• Bryn Mawr College · US

Inventors

• Amos B. Smith, III · Yeadon, US
• Joseph Sodroski · Medford, US
• Navid Madani · Newton, US
• Bruno Melillo · Philadelphia, US
• Judith M. LaLonde · Havertown, US
• Amy M. Princiotto · Attleboro, US

Key dates

• Filing date: Aug 13, 2015
• Grant date: May 22, 2018
• Expiry date: Aug 13, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.