Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein

US9975853B2 · kind B2 · utility

Inventors

• Manik Chatterjee · Würzburg, DE
• Andreas Hartung · Rannungen, DE
• Ulrike Holzgrabe · Eibelstadt, DE
• Elisabeth Mueller · Frankenthal (Pfalz), DE
• Ulrich Peinz · Peine, DE
• Christoph Sotriffer · Gerbrunn, DE
• David Zilian · Würzburg, DE

Key dates

• Filing date: Jun 3, 2014
• Grant date: May 22, 2018
• Expiry date: Jun 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the inhibition of the Hsp70 protein. The compounds are useful in the treatment or inhibition of cancer, autoimmune disease, rheumatoid arthritis, inflammatory bowel disease and psoriasis.