Inhibitors of transcription factors and uses thereof

US9975896B2 · kind B2 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• University of Massachusetts · US

Inventors

• Jason J. Marineau · Franklin, US
• James E. Bradner · Weston, US
• Wei Zhang · Brecksville, US
• Jun Qi · Sharon, US
• Michael R. McKeown · Brookline, US
• Harry Hongning Fu · Newton, US
• Shuai Liu · Beijing, CN

Key dates

• Filing date: Jul 25, 2014
• Grant date: May 22, 2018
• Expiry date: Jul 25, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.