Antibacterial compounds and biological applications thereof

US9975911B2 · kind B2 · utility

Assignee

• MUTABILIS · FR

Inventors

• Dmytro Atamanyuk · Chelles, FR
• Vincent Gerusz · San Antonio, US
• Francois Moreau · Issy-les-Moulineaux, FR
• Vivien Henryon · Val-de-Reuil, FR
• Jerome Monbrun · Vienne, FR
• Etienne Airiau · Vienne, FR

Key dates

• Filing date: Oct 28, 2013
• Grant date: May 22, 2018
• Expiry date: Oct 28, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, A1 and A2, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkyl-ORa, (C1-C6) alkyl-SRa, (C1-C6) alkyl-NRaRb, ORa, SRa, NRaRb, or CORa; A3 is H, OH or form a carbonyl with A4; A4 is H, OH or form a carbonyl with A3; A5 is H, CRaRbOH, F, OH or forms a double bond with X in the case where X is CH; A6 is H or F; X is CH2, CHF, CF2, CHOH, O, S, NRa or a simple bond, or X is CH in the case where A5 forms with X a double bond; Y is P(O)(ORa)(ORb) or P(O)(ORa)(NRaRb); V is O or S; A7 is H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl or (C1-C6) alkyl-ORa; A8 is OH or H, Ra and Rb, identical or different, are H, (C1-C6) alkyl, (C1-C6) fluoroalkyl, (C1-C6) alkyl-OH or (C1-C6) alkyl-O—(C1-C6) alkyl; and their addition salts thereof with acids and bases, their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity.