Patent · US Active

Polypeptides

US9975943B2 · kind B2 · utility

2Cited by

5References

46Claims

0Family size

Assignee

AFFIBODY AB · SE

Inventors

Caroline Ekblad · Boo, SE
Elin Gunneriusson · Hallsberg, SE
Malin Lindborg · Boo, SE
Lars Abrahmsen · Bromma, SE
John Löblom · Huddinge, SE
Torbjörn Gräslund · Åtvidaberg, SE
Johan Seijsing · Stockholm, SE

Key dates

Filing date	Mar 17, 2014
Grant date	May 22, 2018
Priority date	—
Expiry date	Mar 17, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/74
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.