Antibodies obtainable using supramolecular constructs

US9975946B2 · kind B2 · utility

Assignee

• AC Immune SA · CH

Inventors

• Yves Claude Nicolau · Newton, US
• Ruth Greferath · Kehl, DE
• David Hickman · Yverdon-les-Bains, CH

Key dates

• Filing date: Nov 26, 2014
• Grant date: May 22, 2018
• Expiry date: Jul 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, P170 glycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.