Administration of kynurenine depleting enzymes for tumor therapy

US9975959B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• George Georgiou · Austin, US
• Everett Stone · Austin, US
• Nicholas Marshall · Rahway, US
• John Blazeck · Austin, US
• Wei Lu · Sichuan, CN

Key dates

• Filing date: Aug 28, 2015
• Grant date: May 22, 2018
• Expiry date: Sep 30, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.