OPAA FL—a mutant enzyme with increased catalytic efficiency on organophosphorus compound GD

US9976130B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Mark A. Guelta · White Marsh, US
• Melissa M Dixon · Milford, US
• Steven P. Harvey · Timonium, US

Key dates

• Filing date: Dec 30, 2016
• Grant date: May 22, 2018
• Expiry date: Dec 30, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A62D2101/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed toward a non-wild-type organophosphorus acid anhydrolase enzyme having two site mutations, method of production, and method of use to more effectively degrade toxic organophosphorus compounds and, in particular, toxic chemical GD (3,3-Dimethylbutan-2-ylmethylphosphonofluoridate), than the wild type organophosphorus acid anhydrolase.