Patent · US Active

Compositions and methods for inhibiting gene expression of Hif2alpha

US9976141B2 · kind B2 · utility

3Cited by

4References

32Claims

0Family size

Assignee

Arrowhead Pharmaceuticals, Inc. · US

Inventors

So Wong · Oregon, US
David L. Lewis · Madison, US
David B. Rozema · Madison, US
Darren H. Wakefield · Fitchburg, US
Steven B. Kanner · Berkeley, US
Weijun Cheng · Middleton, US
Lauren J. Almeida · Madison, US
Andrei V. Blokhin · Fitchburg, US
Jeffrey C. Carlson · Madison, US
Anthony Nicholas · Oregon, US
Aaron Almeida · Madison, US
Jonathan D. Benson · Stoughton, US
Justin Woods · Fitchburg, US

Key dates

Filing date	May 27, 2016
Grant date	May 22, 2018
Priority date	—
Expiry date	May 27, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2α RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2α RNAi triggers to tumor cells in vivo provides for inhibition of Hif2α gene expression and treatment of cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.