CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ tregs
US9977021B2 · kind B2 · utility
1Cited by
4References
10Claims
0Family size
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Key dates
| Filing date | Mar 24, 2015 |
| Grant date | May 22, 2018 |
| Priority date | — |
| Expiry date | May 7, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/7155
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.