Preparation of pH-responsive nanoparticles and promoted delivery of anticancer drugs into deep tumor tissues and application thereof
US9980919B2 · kind B2 · utility
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Key dates
| Filing date | Nov 4, 2015 |
| Grant date | May 29, 2018 |
| Priority date | — |
| Expiry date | Nov 4, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/186
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pH-responsive nanoparticle made of a pH-responsive polymer and a poly(lactic-co-glycolic acid) by self-assembly includes a polyethylene glycol derivative and a R-Histidine derivative that are subjected to a chemical reaction to form the pH-responsive polymer, wherein the surface electric potential of the pH-responsive nanoparticle is −25 to 10 mV, such that when a pH value of the pH-responsive nanoparticle is changed from 7.4 to 5.0 depending upon an external environment, a surface zeta potential of the pH-responsive nanoparticle is converted from negative charge to positive charge.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.