Inhibitors of histone deacetylase

US9981920B2 · kind B2 · utility

Assignee

• Rodin Therapeutics, Inc. · US

Inventors

• Martin R. Jefson · Stonington, US
• Fabian Dey · Basel, CH
• Konstanze Konig von Paumbshausen · Birkenfeld, DE
• Adrian Schomburg · Bogen, DE
• Andreas Schoop · Overath, DE
• Russell Thomas · Verona, IT

Key dates

• Filing date: Jun 25, 2015
• Grant date: May 29, 2018
• Expiry date: Jun 25, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.