Piperidine substituted pyrazolo[1,5-A]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)

US9981976B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Abdellah Tahari · Beerse, BE
• Sandrine Marie Helene Vendeville · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe, BE
• Tim Hugo Maria Jonckers · Heist-op-den-Berg, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE
• Samuël Dominique Demin · Ekeren, BE
• Lili Hu · Mechelen, BE
• Ludwig Paul Cooymans · Beerse, BE

Key dates

• Filing date: Dec 7, 2015
• Grant date: May 29, 2018
• Expiry date: Dec 7, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.