Patent · US Active

Binding polypeptides having a mutated scaffold

US9982022B2 · kind B2 · utility

4Cited by

2References

16Claims

0Family size

Assignee

AFFIBODY AB · SE

Inventors

Erik Nordling · Danderyd, SE
Joakim Nilsson · Danderyd, SE
Patrik Strömberg · Sollentuna, SE

Key dates

Filing date	Aug 28, 2014
Grant date	May 29, 2018
Priority date	—
Expiry date	Aug 10, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.