Control of rheological properties of mixed hyaluronate/lubricin solutions
US9982027B2 · kind B2 · utility
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44References
7Claims
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Key dates
| Filing date | Aug 22, 2014 |
| Grant date | May 29, 2018 |
| Priority date | — |
| Expiry date | Aug 22, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are mixed solutions of PRG4 and hyaluronic acids having controlled, enhanced rheological properties adapted for various particular medical and cosmetic uses. Such solutions combine the solution-based lubrication ability of HA and the boundary-based lubricating effects of lubricin. Being more viscous, the solutions when used for joint viscosupplementation enhance both the duration of the HA within the joint capsule (in vivo half-life) and enhance the cushioning effects of the HA, as well as improve both solution and boundary mode lubrication mechanisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.