Patent · US Active

Modified gram positive bacteria and uses thereof

US9982228B2 · kind B2 · utility

2Cited by

6References

18Claims

0Family size

Assignee

INTREXON ACTOBIOTICS N.V. · BE

Inventors

Lothar Steidler · Lokeren, BE
Karolien Van Huynegem · Asper, BE
Klaas Vandenbroucke · Zevergem, BE

Key dates

Filing date	Jan 21, 2016
Grant date	May 29, 2018
Priority date	—
Expiry date	Jan 21, 2036

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/52
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.