Patent · US Active

Compositions and methods for reprograming non-pluripotent cells into pluripotent stem cells

US9982237B2 · kind B2 · utility

2Cited by

12References

21Claims

0Family size

Assignee

Hong Guan Ltd. · CN

Inventors

Hongkui Deng · Beijing, CN
Yang Zhao · North Andover, US
Pingping Hou · Beijing, CN
Yanqin Li · Lo Wu, CN
Xu Zhang · Shanghai, CN
Chun-Min Liu · Laishui, CN
Jingyang Guan · Beijing, CN
Honggang Li · Beijing, CN

Key dates

Filing date	Jul 10, 2014
Grant date	May 29, 2018
Priority date	—
Expiry date	Aug 14, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/1384
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides a composition and a method for inducing pluripotency in non-pluripotent eukaryotic cells. The composition comprises chemical inducers of pluripotency (CIPs) including glycogen synthase kinase (GSK) inhibitors, TGFp receptor inhibitors, cyclic AMP agonists, S-adenosylhomocysteine hydrolase (SAH) inhibitors, and optionally an agent that promotes histone acetylation. The method comprises contacting a cell with the CIPs for a sufficient period of time to reprogram the cell into a pluripotent stem cell.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.