Bacterial strain of Actinoplanes sp. and application thereof

US9982314B2 · kind B2 · utility

Assignee

• Zhejiang Hisun Pharmaceutical Co., Ltd. · CN

Inventors

• Hao Xu · Chengdu, CN
• Fei Tang · Washington, US
• Peijun Zhan · Zhejiang, CN
• Jianhong Hu · Zhejiang, CN
• Huijun Ren · Zhejiang, CN
• Hongmei Fan · Zhejiang, CN
• Linghui Zheng · Shanghai, CN
• Hua Bai · Lake Jackson, US

Key dates

• Filing date: Oct 14, 2014
• Grant date: May 29, 2018
• Expiry date: Oct 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/045
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A bacterial strain of Actinoplanes sp. and and the use thereof. The bacterial strain is named Actinoplanes sp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on Clostridium difficile.