Methods of improving RNAi in well-differentiated airway epithelia
US9987299B2 · kind B2 · utility
0Cited by
7References
13Claims
0Family size
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Key dates
| Filing date | May 4, 2015 |
| Grant date | Jun 5, 2018 |
| Priority date | — |
| Expiry date | May 4, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.