Catalytic hydrogenation of nitriles

US9988353B2 · kind B2 · utility

Assignee

• BAYER CROPSCIENCE AKTIENGESELLSCHAFT · DE

Inventors

• Wahed Ahmed Moradi · Monheim, DE
• Thomas Himmler · Odenthal, DE
• Thomas Mueller · Wehr, DE
• Albert Schnatterer · Leverkusen, DE
• Guenter Schlegel · Leverkusen, DE

Key dates

• Filing date: Nov 11, 2014
• Grant date: Jun 5, 2018
• Expiry date: Nov 11, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/89
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.