Heterocyclic triazole compounds as agonists of the APJ receptor

US9988369B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Xiaoqi Chen · Palo Alto, US
• Yinhong Chen · Hayward, US
• Alan C. Cheng · Cambridge, US
• Richard V. Connors · Mesa, US
• Mikkel V. Debenedetto · Shrewsbury, US
• Paul John Dransfield · Arlington, US
• Zice Fu · Foster City, US
• James S. Harvey · Arlington, US
• Julie Anne Heath · Chico, US
• Simon J. Hedley · Thousand Oaks, US
• Jonathan Houze · Cambridge, US
• Ted Judd · San Fernando, US
• Aarif Yusuf Khakoo · Woodside, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Nobuko Nishimura · Calabasas, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Gayathri Swaminath · Brisbane, US
• Xiaodong Wang · Zhejiang, CN
• Wen-Chen YEH · Belmont, US

Key dates

• Filing date: May 2, 2017
• Grant date: Jun 5, 2018
• Expiry date: May 2, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.