Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof

US9988381B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. · CN

Inventors

• Jingkang Shen · Shanghai, CN
• Meiyu Geng · Shanghai, CN
• Jian Ding · Shanghai, CN
• Bing Xiong · Shanghai, CN
• Jing Al · Shanghai, CN
• Yuchi Ma · Lo Wu, CN
• Xin Wang · Shanghai, CN
• Xia Peng · Shanghai, CN
• Yuelei Chen · Shanghai, CN
• Danqi Chen · Shanghai, CN
• Tao Meng · North Plainfield, US
• Lanping Ma · Shanghai, CN
• Yinchun JI · Shanghai, CN

Key dates

• Filing date: Jun 18, 2014
• Grant date: Jun 5, 2018
• Expiry date: Jun 18, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase.