Processes for making ponatinib and intermediates thereof

US9988389B2 · kind B2 · utility

Assignee

• Apicore US LLC · US

Inventors

• Ravishanker Kovi · Sparta, US
• Jayaraman Kannapan · Sayla, IN
• Sanjay F. Thakor · Sayla, IN
• Ashish Naik · Piscataway, US
• Dhakhada Chetana Bharatbhai · Sayla, IN
• Khichi Kuldip Fatehlal · Sayla, IN
• Shivnath Sahebrao Patil · Dhule, IN

Key dates

• Filing date: Jun 10, 2016
• Grant date: Jun 5, 2018
• Expiry date: Jun 10, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.