Non-natural amino acid tRNA synthetases for pyridyl tetrazine
US9988619B2 · kind B2 · utility
16Cited by
1References
10Claims
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Key dates
| Filing date | Oct 10, 2014 |
| Grant date | Jun 5, 2018 |
| Priority date | — |
| Expiry date | Jan 12, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y601/01001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also provided are methods for incorporating the non-natural amino acids, pyridinyl-amino tetrazine amino acids, into a protein, and further conjugating a biologically active adduct to the pyridinyl-amino tetrazine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.