Methods, compositions, and kits for the treatment of matrix mineralization disorders
US9988620B2 · kind B2 · utility
22Cited by
13References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2011 |
| Grant date | Jun 5, 2018 |
| Priority date | — |
| Expiry date | Jun 8, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods, compositions, and kits for the treatment of matrix mineralization disorders such as hypophosphatasia. In particular, the present invention provides polypeptides having a soluble alkaline phosphatase fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to patients, e.g., subcutaneously, to treat hypophosphatasia using enzyme replacement therapy. The invention also features nucleic acids encoding such polypeptides and the use of the nucleic acids for treating matrix mineralization disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.