Detecting and visualizing correlations between measured correlation values and correlation reference values of a pathway

US9990713B2 · kind B2 · utility

Assignee

• Definiens GmbH · DE

Inventors

• Ralf Schoenmeyer · Gilching, DE
• Sonja Althammer · Burghausen, DE
• Guenter Schmidt · Leun, DE

Key dates

• Filing date: Jun 9, 2016
• Grant date: Jun 5, 2018
• Expiry date: Jun 9, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H50/20
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

An analysis and visualization system analyzes a digital image of a tissue sample. In the sample, cells of a first type are stained in a first way, and cells of a second type are stained in a second way. The system segments the high-resolution image into first and second objects representing cells of the first and second types, respectively. The system also identifies a region of interest, and divides it into tiles. The system generates, for each tile, a first value and a second value. The first and second values for a tile are indicative of densities of the first and second objects in the tile. From the values, a measured correlation coefficient (CC) value is determined. The system compares the measured CC value to a reference CC value, thereby obtaining a correspondence value. The system then displays the image region along with a visualization of the correspondence value.